Not much is known about her early life, other than that Ophelia was raped during her childhood.
- "Don't you know a ViP when you see one? Your boss came out of my V and her daddy’s P. Show a little respect for her mama."
Ophelia and Annalise have a strained relationship. Ophelia believes that Annalise became arrogant when she became rich and forgot about her roots. She also insists on calling Annalise her birth name, Anna Mae. Ophelia has never visited Annalise's house and hasn't seen her in years.
When Annalise blames Ophelia for letting her uncle Clyde rape her when she was a child, Ophelia reveals that when she found out about what Clyde was doing, she burned her house down with him sleeping inside of it.
In the fourteenth episode of this season Annalise goes to see her Mother in Memphis because she seems to be overwhelmed by the things going on in her office. Ophelia hosts a small family get together which isn't really appreciated by Annalise. Annalise's Father Mac Harkness also makes an appearance at this event. Annalise learns about the newly lit romance between her mother and father.
Later on when Nate comes to visit Annalise in Memphis Ophelia invites him in and asks him all kinds of personal questions. That night Ophelia learns about Annalise's dead baby and they go and hold a funeral in their garden.
Annalise singing to her mother. ("I'm Going Away")
A couple of months later, her daughter, Annalise came to visit her. Ophelia, her two daughters, and Mac sat down at the table to talk. Annalise and Celestine have been taking and Annalise said she wanted to use her insurance money from the fire to put her mom in a nursing home, but her mother was furious with the idea. During the night, Ophelia had a dementia episode, after which she agreed to visit the facility. Annalise’s father wanted to care for her herself, and they fought over who was to blame for her mom’s condition. Celestine assured her that it wasn’t her fault, and she confessed that the expected insurance payout wasn’t coming through. She further admitted she may be disbarred for her alcohol issues. “I’d be drinking, too, if I had your life,” her sister admitted. Annalise asked her mom point-blank what she wants to do, and the matriarch replied, “I’m going away. You know it, I know it. My mind’s going.” Noting her daughter’s past losses, she said she wanted to “protect you from losing anymore.” But since dementia can’t be stopped, she said they need to “prepare,” prompting Annalise to break down. “Don’t worry, I’ll stay as long as I can,” her mother said. Before leaving, Annalise begged her dad to “keep her safe,” at which pointed he finally apologized for the sexual assault she suffered at the hands of his brother. ("I'm Going Away")
Ophelia helping Olivia fix her jacket. ("Lahey v. Commonwealth of Pennsylvania")
Her daughter, Annalise, called her to tell her that she had managed to get her case sent to the Supreme Court and that she wanted her and Mac to come to D.C. to see her in action. Delighted with the news, Ophelia agreed. Once they arrived at Annalise's hotel room, she and Mac were introduced to Olivia Pope who Ophelia recognized from the 'telly.' Ophelia encouraged the two to eat with them as they had brought sandwiches. Olivia was worried that it would be a waste of their time but Annalise insisted. After their lunch, Nate arrived to which Ophelia was delighted by the surprise. In Supreme court, Ophelia was having one of her episodes when she saw Annalise about to go into the courtroom. Already late, Olivia encouraged Annalise to go inside and let her deal with her mother. Ophelia accidentally knocked over some stew onto Olivia's blouse. Olivia, again, urged Annalise to go inside as she was already late. Ophelia and Olivia then went to the bathroom where she tried to get the stain out of her jacket. They ended up having a heartwarming talk before entering the courtroom late. While at the courtroom, Annalise presented her case to the justices; one of the justices, Justice Strickland was particularly hard on Annalise and Nate Lahey, Sr. (the "face case" of the class action). After the court was adjourned, the decision of the Justices remained unknown. ("Lahey v. Commonwealth of Pennsylvania")
- Clyde Harkness: Killed him and burned his body for what he had done to Annalise. Clyde has sexually assulted her during her childhood. She had gotten away with it as it was ruled an accident. ("Mama's Here Now")
|"Pilot"||"It's All Her Fault"||"Smile, or Go to Jail"||"Let's Get to Scooping"||"We're Not Friends"|
|"Freakin' Whack-a-Mole"||"He Deserved to Die"||"He Has a Wife"||"Kill Me, Kill Me, Kill Me"||"Hello Raskolnikov"|
|"Best Christmas Ever"||"She's a Murderer"||"Mama's Here Now"||"The Night Lila Died"||"It's All My Fault"|
|"It's Time to Move On"||"She's Dying"||"It's Called the Octopus"||"Skanks Get Shanked"||"Meet Bonnie"|
|"Two Birds, One Millstone"||"I Want You to Die"||"Hi, I'm Philip"||"What Did We Do?"||"What Happened to You, Annalise?"|
|"She Hates Us"||"It's a Trap"||"Something Bad Happened"||"There's My Baby"||"Anna Mae"|
|"We're Good People Now"||"There Are Worse Things Than Murder"||"Always Bet Black"||"Don't Tell Annalise"||"It's About Frank"|
|"Is Someone Really Dead?"||"Call It Mother's Intuition"||"No More Blood"||"Who's Dead?"||"We're Bad People"|
|"Not Everything's About Annalise"||"Go Cry Somewhere Else"||"It's War"||"He Made a Terrible Mistake"||"Wes"|
|"I'm Going Away"||"I'm Not Her"||"It's for the Greater Good"||"Was She Ever Good at Her Job?"||"I Love Her"|
|"Stay Strong, Mama"||"Nobody Roots for Goliath"||"Live. Live. Live."||"He's Dead"||"Everything We Did Was For Nothing"|
|"He's a Bad Father"||"Ask Him About Stella"||"Lahey v. Commonwealth of Pennsylvania"||"The Day Before He Died"||"Nobody Else Is Dying"|